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{07} {35} {36} Both allopurinol and the uricosuric antigout agents are effective in patients whose 24-hour renal excretion of uric acid is 800 mg (4. Allopurinol will not relieve a gout attack that has already started. {06} {35} {36} However, the uricosuric agents are less toxic than allopurinol and should be considered for use when appropriate {37}. Up to 300 milligrams (mg) of allopurinol can be taken at one time. However, allopurinol did not cause birth defects or other problems in rats or rabbits given doses up to 20 times the amount usually given to humans. Adverse effects can be minimized by increased hydration, urine alkalinization, and the prophylactic administration of a xanthine oxidase inhibitor such as ZYLOPRIMŽ (allopurinol).
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