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« : Styczeń 09, 2010, 03:18:30 »

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Case reports have suggested that thiazide diuretics may increase the risk of allopurinol-induced hypersensitivity reactions, especially in patients with renal insufficiency. It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients. Unlike PURINETHOL (mercaptopurine) and IMURANŽ (azathioprine), Thioguanine may be continued in the usual dosage when allopurinol is used conjointly to inhibit uric acid formation. {06} {35} {36} However, the uricosuric agents are less toxic than allopurinol and should be considered for use when appropriate {37}. The product of methylation, 2-amino-6-methylthiopurine, is also substantially less active and less toxic than Thioguanine and its formation is likewise unaffected by the presence of allopurinol.

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